Lack of a relationship between Lewis antigen expression and cagA, CagA, vacA and VacA status of Irish Helicobacter pylori isolates

cagA and vacA status of Spanish Helicobacter pylori clinical isolates.

Helicobacter pylori is a gram-negative rod associated with gastroduodenal pathologies, such as gastritis, peptic ulcer, and gastric adenocarcinoma. Although most H. pylori infections are clinically silent, the organism is associated with substantial morbidity and mortality. It is unknown why the bacteria are able to produce severe disease in some hosts and be innocuous in others. Different viru...

Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms.

BACKGROUND & AIMS The Helicobacter pylori gene cagA and s1 or m1 forms of vacA are more common in disease-associated strains. Recently, forms of cagA encoding multiple type C EPIYA segments (which increase phosphorylation-dependent CagA activity) and a new type i1 "intermediate region" polymorphism in vacA (which confers toxicity) have been described. We assessed the association of new and esta...

Helicobacter pylori cagA Status, vacA Subtypes and Histopathologic Findings in Iranian Patients with chronic gastritis

  Background and Objective: Helicobacter pylori has several strains with different degrees of virulence. The aim of this study was to detect two major important virulence factors, cagA/vacA genotypes, and to determine correlations among different cagA/vacA genotypes and histological features of chronic gastritis in Iranian patients. Methods: In this cross- sectional study, Gastric bi...

[Helicobacter pylori: focus on CagA and VacA major virulence factors].

After colonizing the human gastric mucosa, Helicobacter pylori can remain within the host for years and even decades, and is associated with several, highly significant gastric pathologies. In Mexico, the seroprevalence at 1 year of age is 20% and the estimated increment in seropositivity per year is 5% for children aged 1-10 years. More than 80% of adults are infected by the time they are 18-2...

Relationship between J-Western CagA subtype and the vacA m2 region of Helicobacter pylori.